Caldesmon (h-CD)

CALDESMON

Description

Cytokeratins

5 and 6; stratified squamous epithelial cytokeratin

Aids in diagnosing low-differentiated pavement epithelium carcinoma, adenocarcinoma, and mesothelioma

Differentiates epithelial mesotheliomas (positive-cytoplasmic staining with perinuclear enhancement) from lung adenocarcinoma (89% sensitive and 95% specific)

Methodology: Immunohistochemistry

TAT: 3-5 days

Specimen Preparation
Collect - tissue /or cell
Specimen Preparation- formal fix (10 % neutral buffered formalin) and paraffin enter specimen (FFPE specimens square measure needed). shield paraffin block or slides from uncontrolled heat. Transport tissue block or five unstained (3-micron thick sections), charged slides during a tissue transport kit. (Min: a pair of slides). If causing precut slides, don't over heat it.
Storage/Transport Temperature- At temperature or cold. Transport it in cooled instrumentation throughout weather.
Unacceptable conditions- i) Specimens submitted with non-marked/tagged tissue sort square measure rejected.
ii) Depleted specimens aren't tested.
Stability- i) Ambient: Indefinitely;
ii) Refrigerated: Indefinitely;
iii) Frozen: Unacceptable