CD43 (L60, Leu 22)
What does the CD43 (L60, LEU 2, test measure?
CD43, also known as leukosialin or sialophorin, is a glycoprotein that is found on the surface of white blood cells, especially on T-lymphocytes and B-lymphocytes. CD43 plays an important role in cell adhesion, migration, and activation of immune cells. The L60 and LEU 2 tests measure the expression levels of CD43 on white blood cells, which can be helpful in diagnosing and monitoring certain types of leukemias, lymphomas, and other immune system disorders. High levels of CD43 expression may indicate an abnormal proliferation of white blood cells, while low levels of CD43 may indicate a deficiency in immune cell function.
What kind of sample is needed for the CD43 (L60, LEU 2, test?
In order to conduct the CD43 (L60, LEU 2) test, a blood sample is typically needed. The test involves analyzing the expression of the CD43 protein on the surface of white blood cells, which can be done by staining and analyzing a sample of blood. It is important to consult with a healthcare provider to determine if this test is necessary and to properly prepare for the sample collection process.
How is the CD43 (L60, LEU 2, test performed?
The CD43 (L60, LEU 2) test is a laboratory test that is performed on a blood sample. The test helps to measure the levels of the CD43 protein in the blood. The CD43 protein is found on the surface of white blood cells and is involved in regulating the immune system.
To perform the CD43 test, a blood sample is typically collected from a vein in the arm. The sample is then sent to a laboratory where it is processed and analyzed. The laboratory uses specialized equipment and techniques to measure the levels of CD43 in the blood sample.
The CD43 test is often ordered by doctors to help diagnose and monitor certain medical conditions, such as leukemia and other blood disorders. The test results can also be used to evaluate the effectiveness of certain medical treatments.
It is important to note that the CD43 test is a medical test and should only be performed by a qualified healthcare professional. If you have any questions or concerns about the CD43 test, you should speak with your doctor or a healthcare provider.
What happens if the CD43 (L60, LEU 2, the test is abnormal?
CD43 (L60, LEU 2) is a glycoprotein that is expressed on the surface of various types of blood cells, including white blood cells. Abnormal levels of CD43 can indicate certain medical conditions.
If the CD43 test is abnormal, it can suggest several different things, depending on the context of the test. For example, elevated levels of CD43 may be seen in certain types of leukemia or lymphoma, as well as in autoimmune disorders such as rheumatoid arthritis and lupus.
On the other hand, decreased levels of CD43 may suggest certain types of immune deficiencies, such as severe combined immunodeficiency (SCID).
It is important to note that an abnormal CD43 test result alone is not enough to make a diagnosis. Your doctor will likely order other tests and perform a physical exam to determine the underlying cause of any abnormalities.
What patient preparation is required for a CD43 (L60, Leu 2, test?
If your healthcare provider has ordered a CD43 test for you, there are a few steps you may need to take to prepare for the test.
Firstly, your healthcare provider may ask you to fast for a certain amount of time before the test. This means that you should not eat or drink anything except for water for a few hours before the test. Fasting is usually required when the test is being done to evaluate certain health conditions such as diabetes.
Secondly, you may need to stop taking certain medications before the test. Some medications can interfere with the accuracy of the test results, so your healthcare provider may ask you to temporarily stop taking them. It's important to follow their instructions carefully and not stop taking medication without consulting them first.
Finally, you should inform your healthcare provider if you are pregnant or if you have any bleeding disorders. This information can affect the way the test is performed and the interpretation of the results.
Overall, the patient preparation for a CD43 test is relatively simple and straightforward. Just follow your healthcare provider's instructions carefully, and you should be well prepared for the test.
What do the results of the CD43 (L60, LEU 2, test indicate?
The CD43 (L60, LEU 2) test is a type of flow cytometry test that is used to identify the presence of a protein called CD43 on the surface of cells. CD43 is a glycoprotein that is commonly found on the surface of white blood cells, particularly T cells and B cells.
The results of the CD43 (L60, LEU 2) test can indicate several things. If CD43 is present on the surface of the cells being tested, this can indicate that the cells are white blood cells, which is helpful in diagnosing certain types of blood cancers. On the other hand, if CD43 is not present on the surface of the cells being tested, this can indicate that the cells are not white blood cells, which can be helpful in ruling out certain types of blood disorders.
Overall, the CD43 (L60, LEU 2) test is a useful tool for identifying and diagnosing blood disorders, particularly those related to white blood cells. However, it is important to interpret the results of this test in conjunction with other diagnostic tests and clinical information to arrive at an accurate diagnosis.
Description- CD43 is expressed on T lymphocytes, B lymphocytes, and granulocytes and it aids in identifying cells of lymphoid lineage, T-cell lymphomas, and mantle-cell lymphomas
Methodology: Immunohistochemistry
TAT: 3-5 days
Specimen Preparation
Collect - tissue /or cell
Specimen Preparation- formal fix (10 % neutral buffered formalin) and paraffin enter specimen (FFPE specimens square measure needed). shield paraffin block or slides from uncontrolled heat. Transport tissue block or five unstained (3-micron thick sections), charged slides during a tissue transport kit. (Min: a pair of slides). If causing precut slides, don't over heat it.
Storage/Transport Temperature- At temperature or cold. Transport it in cooled instrumentation throughout weather.
Unacceptable conditions- i) Specimens submitted with non-marked/tagged tissue sort square measure rejected.
ii) Depleted specimens aren't tested.
Stability- i) Ambient: Indefinitely;
ii) Refrigerated: Indefinitely;
iii) Frozen: Unacceptable
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