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MDM2(12q15) Gene Amplification- FISH
What is the function of the mdm2 gene?
The mdm2 gene is an important gene involved in a wide range of cellular processes. It is a negative regulator of the tumor suppressor p53, which helps regulate cell growth and prevent tumor development. It also binds to several other proteins involved in cell cycle regulation, DNA repair, and apoptosis, making it an essential gene for proper cellular functioning. In addition, mdm2 has been found to be involved in the development of certain types of cancer and has been implicated in chemotherapy resistance. Therefore, it is clear that the mdm2 gene plays a vital role in many different cellular processes.
What is the significance of mdm2 (12q1, gene amplification?
Mdm2 (12q1, gene amplification) is a gene that plays an important role in the regulation of the p53 tumor suppressor gene. The increased expression of Mdm2 in cells with amplified p53 gene is a major mechanism for its anti-apoptotic effects. This is significant because it is a key factor in understanding the relationship between p53 and cancer. Research has shown that increased expression of Mdm2 in cells with amplified p53 gene is associated with more aggressive tumors and worse prognoses in cancer patients. Thus, understanding the role of Mdm2 in regulating p53 is important for the development of new treatments and therapies to combat cancer.
How common is mdm2 (12q1, gene amplification?
Mdm2 (12q1) gene amplification test in is not a common phenomenon. It is found in certain types of cancer, primarily in soft tissue sarcomas, breast cancer, and chronic myeloid leukemia. It is also seen at low frequency in other cancers, such as prostate cancer and ovarian cancer. Mdm2 gene amplification is believed to be associated with an increased risk of cancer development and progression, as well as drug resistance. However, it is still not clear how or why the gene is amplified in some tumors.
What are some of the risk factors associated with mdm2 (12q1, gene amplification?
Mdm2 (12q1, gene amplification) is a genetic abnormality that is linked to a number of different cancers, including certain types of leukemia and some types of lymphomas. It is caused by an increase in the number of copies of the Mdm2 gene that is present in the cells of the body. This increase in gene copies can lead to increased activity of the gene, which in turn can encourage the growth and spread of cancer cells.
Some of the risk factors associated with mdm2 (12q1, gene amplification) include a family history of cancer, exposure to radiation, and certain lifestyle choices. Additionally, individuals with certain genetic predispositions may be at an increased risk for developing mdm2 (12q1, gene amplification).
It is important to note that not everyone who has Mdm2 (12q1) gene amplification test cost is Rs. 7,000 will develop cancer, but those who do have a higher risk of developing certain types of cancer. It is important to talk to your doctor about any concerns you may have regarding your risk level.
DESCRIPTION – This test detects for the amplification of MDM2 gene for classification of certain adipocytic tumors. MDM2 amplification are frequently detected in well differentiated liposarcoma which includes atypical lipomatous tumor and in dedifferentiated in liposarcoma. These tumors can be difficult to distinguish morphologically from other high grade sarcomas and benign tumors. Amplifications are detected infrequently in other soft tissues sarcomas, and are not detected in benign lipomas.
Methodology – fluorescence in situ hybridization (FISH)
Turn Around Time – 6 days
Patient Preparation –
Collect – tumor tissue
Specimen Preparation – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat.
Storage/Transport Temperature – room temperature (18-25 degrees C)
STABILITY – ambient: indefinitely; refrigerated: indefinitely
Unacceptable Conditions – alternate fixatives and decalcified specimens
MRP – 7000.00
Special Instructions – tissue block must contain 10% of tumor tissue. Clinical history is mandatory including surgical pathology reports
FAQ
What is the MDM2 12q15 gene amplification FISH test?
The MDM2 12q15 gene amplification FISH test is a diagnostic test used to detect genetic abnormalities in cancer cells. This test uses fluorescent in situ hybridization (FISH) technology to analyze the genetic material of cancer cells and identify any abnormalities in the MDM2 gene. The MDM2 gene is associated with the regulation of cell growth and division, and amplification of this gene can contribute to the development and progression of certain cancers.
Where can I get an MDM2 12q15 gene amplification FISH test in Delhi?
There are several laboratories and hospitals in Delhi that offer MDM2 12q15 gene amplification FISH tests. Some examples include Dr. Lal PathLabs, SRL Diagnostics, and Metropolis Healthcare. It is recommended that you consult with your doctor or healthcare provider to determine the best laboratory or hospital for your specific needs.
How is the MDM2 12q15 gene amplification FISH test performed?
The MDM2 12q15 gene amplification FISH test is typically performed on a sample of tissue or cells collected from a patient's tumor or cancerous growth. The sample is prepared and analyzed using FISH technology, which involves labeling specific genetic markers with fluorescent dyes and then visualizing them under a microscope. The test results can be used to diagnose cancer and determine the appropriate treatment options.
What are the risks associated with the MDM2 12q15 gene amplification FISH test?
The MDM2 12q15 gene amplification FISH test is a relatively safe procedure, but there is a small risk of complications associated with tissue or cell collection, such as bleeding or infection. It is important to discuss any concerns or questions you may have about the risks of the test with your healthcare provider.
How long does it take to get the results of an MDM2 12q15 gene amplification FISH test?
The length of time it takes to receive the results of an MDM2 12q15 gene amplification FISH test can vary depending on the laboratory or hospital performing the test. In general, results are usually available within a few days to a week after the sample is collected. Your doctor or healthcare provider will inform you of the expected timeline for receiving your results.
Pre-Test Information
Clinical History is Mandatory, Tissue block must contain at least 10% tumortissue.
Clinical History is Mandatory, Tissue block must contain at least 10% tumortissue.
₹7,000.00
Home Collection-
Offer Price₹ 7,000.00
Total Amount₹ 7,000.00
*inclusive of all the taxes, fees and subject to availability