NRAS mutations Exon-1 & 2 Tissue
DESCRIPTION – determination of NRAS status plays a role in determining the outcome of therapy in colorectal carcinoma. Absence of NRAS mutation within the tumor suggests that the patient may respond to the therapy but other mutation such as EGFR, KRAS etc. also needs to be checked prior to NRAS
TEST CODE – ME1069
METHODOLOGY – real time polymerase chain reaction (real time PCR)
TURN AROUND TIME – 8 days
PATIENT PREPARATION –
COLLECT – tumor tissue
SPECIMEN PREPARATION – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat.
STORAGE/TRANSPORT TEMPERATURE – room temperature (8-25 degrees C)
STABILITY – ambient: indefinitely; refrigerated: indefinitely
UNACCEPTABLE CONDITIONS – alternate fixatives and decalcified specimens
MRP – 6000
SPECIAL INSTRUCTIONS – clinical history is mandatory
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13th day
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Tissue