PDGFRB,(5q32) GeneRearrangement

DESCRIPTION – this gene is located at 5q32. PDGFRB stands for platelet derived growth factor receptor B. it defines a unique subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and characterized by high sensitivity to tyrosine kinase inhibition.

CLINICAL UTILITY – for diagnosis of myeloproliferative /myelodysplastic syndrome with eosinophilia

METHODOLOGY – fluorescence in situ hybridization (FISH)

TURN AROUND TIME – 7 days

PATEINT PREPARATION –

COLLECT – non diluted bone marrow aspirate or sodium heparin

SPECIMEN PREPARATION – 3-4 ml bone marrow or peripheral blood in green top (sodium heparin) or lavender top (EDTA) tube

STORAGE/TRANSPORT TEMPERATURE – 2-8 degrees C (with cold pack) and transport within 72 hours

STABILITY – ambient: 48 hours; refrigerated: 48 hours

UNACCEPTABLE CONDITIONS – frozen and clotted specimens

MRP – 3500.00

SPECIAL INSTRUCTIONS – clinical history is mandatory