ROS -1

DESCRIPTION – ROS 1 gene is located at 6q22. ROS 1 is a receptor of tyrosine kinase. The ROS 1 gene fuses with part of another gene and activates ROS 1 gene which causes uncontrolled cell growth and leads to cancer.

CLINICAL UTILITY – to identify NSCLC patients who can benefit from crizotinib therapy

METHODOLOGY – fluorescence in situ hybridization (FISH)

TURN AROUND TIME – 6 days

PATIENT PREPARATION –

COLLECT – tumor tissue

SPECIMEN PREPARATION – formalin fixed paraffin embedded tissue block. Protect the slides from excessive heat.

STORAGE/TRANSPORT TEMPERATURE – room temperature (8-25 degrees C)

STABILITY – ambient: indefinitely; refrigerated: indefinitely

UNACCEPTABLE CONDITIONS - alternate fixatives and decalcified specimens

MRP – 7000.00

SPECIAL INSTRUCTIONS – clinical history is mandatory including surgical pathology report